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As is known, the first approach for couples who do not have any evincible problem, in other words, were diagnosed with idiopathic infertility is intrauterine insemination for several times and then in-vitro fertilization treatments if no pregnancy occurs.

The regulation to issue an In-vitro Fertilization Treatment Report in our country stipulates to perform intrauterine insemination twice. However, validity of such approach has started to be discussed all over the world. Researches conducted has shown that in-vitro fertilization may also be considered directly for the couples who have desire to have a baby and do not have any evincible problem. A sample for these studies is the following study.

According to a multi-centered study (1) published in Fertility & Sterility journal which is one of the most reputable infertility journals in the world in August, 2010; In-vitro Fertilization directly has been found more economic and superior than intrauterine insemination for 3 times and then in-vitro fertilization treatment.

Details of the study were; 503 women whose ages ranged between 21 and 39 and who have been diagnosed with idiopathic infertility in USA have been divided into two groups randomly.

Intrauterine insemination by using clomiphene citrate (clomen, seropehen, gonaphene) drug, intrauterine insemination by using FSH (injection treatment) and in-vitro fertilization treatment if no pregnancy occurred have been applied; in-vitro fertilization have been applied to the other group directly and groups have been compared for achievement and cost.

Consequently, in-vitro fertilization treatment directly has been found more successful and economic than the other treatments.

Achievement rate for oral drug + intrauterine insemination has been calculated as 7.6% per application; achievement rate for injection + intrauterine insemination has been found as 9.8% and achievement rate for in-vitro fertilization directly has been found as 30.7%. For cost analysis; to choose in-vitro fertilization directly for a couple desiring pregnancy means a profit of 2,624 USD.


Reindollar RH, Regan MM, Neumann PJ, Levine BS, Thornton KL, Alper MM, Goldman MB. A randomized clinical trial to evaluate optimal treatment for unexplained infertility: the fast track and standard treatment (FASTT)trial. Fertil Steril. 2010 Aug;94(3): 888-99. 

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